Authors
Jin-Shik Park, Shu-Ying Zhang, Sang-Ho Jo, Jae-Bin Seo, Lian Li, Kyung-Woo Park, Byung-Hee Oh, Young-Bae Park, Hyo-Soo Kim
Publication date
2006/4/1
Journal
American heart journal
Volume
151
Issue
4
Pages
864-869
Publisher
Mosby
Description
BACKGROUND
Sympathetic activity mediated by adrenergic receptors (ARs) appears to play an important role in controlling the vasomotor tone and, thus, may be associated with vasospastic angina (VA). We investigated the association of the common functional polymorphisms of the AR gene and VA. The candidates were α2CDel322-325, β1Gly389Arg, β2Arg16Gly, and β2Gln27Glu polymorphisms.
METHODS
Eighty-two patients with VA, confirmed by coronary angiography with or without ergonovine provocation test, and 114 apparently healthy control subjects were investigated for genotype of 4 AR polymorphisms and established risk factors of ischemic heart disease.
RESULTS
The minor alleles were α2CDel322-325, β1Gly389, β2Gly16, and β2Glu27 and their frequencies were 7%, 18%, 42%, and 29%, respectively, in the control subjects of this Korean population, which were different from those of other …
Total citations
Scholar articles
JS Park, SY Zhang, SH Jo, JB Seo, L Li, KW Park… - American heart journal, 2006