Authors
Jonas Richiardi, Andre Altmann, Anna-Clare Milazzo, Catie Chang, M Mallar Chakravarty, Tobias Banaschewski, Gareth J Barker, Arun LW Bokde, Uli Bromberg, Christian Büchel, Patricia Conrod, Mira Fauth-Bühler, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Hervé Lemaître, Karl F Mann, Jean-Luc Martinot, Frauke Nees, Tomáš Paus, Zdenka Pausova, Marcella Rietschel, Trevor W Robbins, Michael N Smolka, Rainer Spanagel, Andreas Ströhle, Gunter Schumann, Mike Hawrylycz, Jean-Baptiste Poline, Michael D Greicius, IMAGEN consortium, Lisa Albrecht, Chris Andrew, Mercedes Arroyo, Eric Artiges, Semiha Aydin, Christine Bach, Tobias Banaschewski, Alexis Barbot, Gareth Barker, Nathalie Boddaert, Arun Bokde, Zuleima Bricaud, Uli Bromberg, Ruediger Bruehl, Christian Büchel, Arnaud Cachia, Anna Cattrell, Patricia Conrod, Patrick Constant, Jeffrey Dalley, Benjamin Decideur, Sylvane Desrivieres, Tahmine Fadai, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Fanny Gollier Briand, Penny Gowland, Bert Heinrichs, Andreas Heinz, Nadja Heym, Thomas Hübner, James Ireland, Bernd Ittermann, Tianye Jia, Mark Lathrop, Dirk Lanzerath, Claire Lawrence, Hervé Lemaitre, Katharina Lüdemann, Christine Macare, Catherine Mallik, Jean-François Mangin, Karl Mann, Jean-Luc Martinot, Eva Mennigen, Fabiana Mesquita de Carvahlo, Xavier Mignon, Ruben Miranda, Kathrin Müller, Frauke Nees, Charlotte Nymberg, Marie-Laure Paillere, Tomas Paus, Zdenka Pausova, Jean-Baptiste Poline, Luise Poustka, Michael Rapp, Gabriel Robert, Jan Reuter, Marcella Rietschel, Stephan Ripke, Trevor Robbins, Sarah Rodehacke, John Rogers, Alexander Romanowski, Barbara Ruggeri, Christine Schmäl, Dirk Schmidt, Sophia Schneider, MarkGunter Schumann, Florian Schubert, Yannick Schwartz, Michael Smolka, Wolfgang Sommer, Rainer Spanagel, Claudia Speiser, Tade Spranger, Alicia Stedman, Sabina Steiner, Dai Stephens, Nicole Strache, Andreas Ströhle, Maren Struve, Naresh Subramaniam, Lauren Topper, Robert Whelan, Steve Williams, Juliana Yacubian, Monica Zilbovicius, C Peng Wong, Steven Lubbe, Lourdes Martinez-Medina, Alinda Fernandes, Amir Tahmasebi
Publication date
2015/6/12
Journal
Science
Volume
348
Issue
6240
Pages
1241-1244
Publisher
American Association for the Advancement of Science
Description
During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated with axonal connectivity in the mouse. The results provide convergent, multimodal evidence that resting-state functional networks correlate with the orchestrated activity of dozens of genes linked to ion channel …
Scholar articles
J Richiardi, A Altmann, AC Milazzo, C Chang… - Science, 2015