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Tanzania is striving to achieve Millennium Development Goals (MDG) 4 and 5 that call for reducing Neonatal and Maternal Mortality Rate (MNMR) by 2015. In 2010, Neonatal Mortality Rate (NMR) was recorded at 51 per 1,000 live births and Maternal Mortality Rate (MMR) at 454 per 100,000 live births. Despite of the devoted efforts and significant progress, still the mortality rate needs attention and effective intervention to cut it down considerably. The capability and power of Information and Communication Technology (ICT) need to be effectively exploited in revolutionizing health sector in Tanzania. The witnessed expansion of mobile phones usage and extended network coverage presents potential opportunity in enhancing quality of Maternal, Neonatal and Child Health (MNCH) services delivery. This paper explores the role of ICT in reducing MMR and NMR, existing solutions are intensely reviewed to discover what is lacking and provide necessary recommendations.