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A great number of Learning Management Systems (LMSs), commercial or open source exists nowadays (eg WebCT, Blackboard, IBM LearningSpace, etc.) offering integrated services such as the creation and distribution of on-line learning material, the communication between stakeholders, the management of the instruction process etc., thus providing the basic software platform for supporting web-based learning in an easy-touse, and pedagogically flexible manner. This paper proposes a framework on the analysis of potentiality and on the evaluation of LMSs’ admissibility. The most commonly used LMSs have been selected for the application of this specific framework. The aim of the evaluation is twofold; to search their usefulness and their quality in use.