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The nurse practitioner role is transformative in primary health care delivery, addressing unmet health care needs worldwide. The lack of role standardization inhibits the nurse practitioner’s ability to cross borders for meaningful practice and scholarly exchanges, to conduct transnational research, and transform health care. This lack of standardization is explored from the perspective of developed and developing countries. One global standard is advocated to deliver on the vision of primary health care. International nursing advocacy groups and regulatory bodies are called upon to embrace one global standard as an opportunity for knowledge transfer across borders and cultures to improve primary health care.