Authors
Alberto Fernández, Javier Quintero, Roberto Hornero, Pilar Zuluaga, Marta Navas, Carlos Gómez, Javier Escudero, Natalia García-Campos, Joseph Biederman, Tomás Ortiz
Publication date
2009/4/1
Journal
Biological psychiatry
Volume
65
Issue
7
Pages
571-577
Publisher
Elsevier
Description
BACKGROUND
Attention-deficit/hyperactivity disorder (ADHD) is defined as the most common neurobehavioral disorder of childhood, but an objective diagnostic test is not available yet to date. Neurophychological, neuroimaging, and neurophysiological research offer ample evidence of brain and behavioral dysfunctions in ADHD, but these findings have not been useful as a diagnostic test.
METHODS
Whole-head magnetoencephalographic recordings were obtained from 14 diagnosed ADHD patients and 14 healthy children during resting conditions. Lempel-Ziv complexity (LZC) values were obtained for each channel and child and averaged in five sensor groups: anterior, central, left lateral, right lateral, and posterior.
RESULTS
Lempel-Ziv complexity scores were significantly higher in control subjects, with the maximum value in anterior region. Combining age and anterior complexity values allowed the correct …
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