Authors
Robert L Hunter, Margaret Olsen, Chinnaswamy Jagannath, Jeffrey K Actor
Publication date
2006/4/1
Journal
The American journal of pathology
Volume
168
Issue
4
Pages
1249-1261
Publisher
Elsevier
Description
Trehalose 6,6′-dimycolate (TDM) is the most abundant, most granulomagenic, and most toxic lipid extractable from the surface of virulent Mycobacterium tuberculosis (MTB). We further examined its toxicity, which requires activation by oily surfaces. Injections of MTB and/or TDM into sensitized mice induced caseating granulomas that centered on oil droplets. If large doses of MTB were injected in saline, caseating granulomas developed in adipose tissue, but MTB with surface TDM removed induced only acute inflammation that did not persist. Variations in protocols produced several variants of caseating granulomas, each with characteristics of human tuberculosis. In each instance, MTB were localized in fat cells or oil drops during initiation of caseating granulomas suggesting that necrosis was caused by activation of the toxicity of TDM toxicity. Evidence extending these findings to the lung was derived from the …
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RL Hunter, M Olsen, C Jagannath, JK Actor - The American journal of pathology, 2006