Authors
Ivo L Hofacker, Martin Fekete, Peter F Stadler
Publication date
2002/6/21
Journal
Journal of molecular biology
Volume
319
Issue
5
Pages
1059-1066
Publisher
Academic Press
Description
Most functional RNA molecules have characteristic secondary structures that are highly conserved in evolution. Here we present a method for computing the consensus structure of a set aligned RNA sequences taking into account both thermodynamic stability and sequence covariation. Comparison with phylogenetic structures of rRNAs shows that a reliability of prediction of more than 80% is achieved for only five related sequences. As an application we show that the Early Noduline mRNA contains significant secondary structure that is supported by sequence covariation.
Total citations
Scholar articles
IL Hofacker, M Fekete, PF Stadler - Journal of molecular biology, 2002