Authors
Ivo L Hofacker, Martin Fekete, Peter F Stadler
Publication date
2002/6/21
Journal
Journal of molecular biology
Volume
319
Issue
5
Pages
1059-1066
Publisher
Academic Press
Description
Most functional RNA molecules have characteristic secondary structures that are highly conserved in evolution. Here we present a method for computing the consensus structure of a set aligned RNA sequences taking into account both thermodynamic stability and sequence covariation. Comparison with phylogenetic structures of rRNAs shows that a reliability of prediction of more than 80% is achieved for only five related sequences. As an application we show that the Early Noduline mRNA contains significant secondary structure that is supported by sequence covariation.
Total citations
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Scholar articles
IL Hofacker, M Fekete, PF Stadler - Journal of molecular biology, 2002