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Motion prediction is the fundamental input for decision-making in autonomous vehicles. The current motion prediction solutions are designed with a strong reliance on black box predictions based on neural networks (NNs), which is unacceptable for safety-critical applications. Motion prediction with high uncertainty can cause conflicting decisions and even catastrophic results. To address this issue, an uncertainty estimation approach based on the deep ensemble technique is proposed for motion prediction in this paper. Subsequently, the estimated uncertainty is considered in the decision-making module to improve driving safety. Firstly, a motion prediction model based on long short-term memory (LSTM) is built and the deep ensemble technique is utilized to obtain both epistemic and aleatoric uncertainty of the prediction model. Besides, an uncertainty-aware potential field is developed to process the prediction …