Authors
Jasvinder A Singh, George A Wells, Robin Christensen, Elizabeth Tanjong Ghogomu, Lara J Maxwell, John K MacDonald, Graziella Filippini, Nicole Skoetz, Damian K Francis, Luciane C Lopes, Gordon H Guyatt, Jochen Schmitt, Loredana La Mantia, Tobias Weberschock, Juliana F Roos, Hendrik Siebert, Sarah Hershan, Chris Cameron, Michael PT Lunn, Peter Tugwell, Rachelle Buchbinder
Publication date
2011
Source
Cochrane database of systematic reviews
Issue
2
Publisher
John Wiley & Sons, Ltd
Description
Background
Biologics are used for the treatment of rheumatoid arthritis and many other conditions. While the efficacy of biologics has been established, there is uncertainty regarding the adverse effects of this treatment. Since important risks such as lymphomas, serious infections and tuberculosis (TB) reactivation may be more common to the biologics but occur in small numbers across the various indications, we planned to combine the results from biologics used in many conditions to obtain much needed risk estimates.
Objectives
To compare the potential adverse effects of tumor necrosis factor inhibitor (adalimumab, certolizumab, etanercept, golimumab, infliximab), interleukin (IL)‐1 antagonist (anakinra), IL‐6 antagonist (tocilizumab), anti‐CD28 (abatacept), and anti‐B cell (rituximab) therapy in patients with any disease condition except human immunodeficiency disease (HIV/AIDS).
Methods
Randomized …
Total citations
Scholar articles
JA Singh, GA Wells, R Christensen, ET Ghogomu… - Cochrane database of systematic reviews, 2011