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Analysis of anomalies that occur during operations is an important means of improving the quality of current and future software. Although the benefits of anomaly analysis of operational software are widely recognized, there has been relatively little research on anomaly analysis of safety-critical systems. In particular, patterns of software anomaly data for operational, safety-critical systems are not well understood. We present the results of a pilot study using orthogonal defect classification (ODC) to analyze nearly two hundred such anomalies on seven spacecraft systems. These data show several unexpected classification patterns such as the causal role of difficulties accessing or delivering data, of hardware degradation, and of rare events. The anomalies often revealed latent software requirements that were essential for robust, correct operation of the system. The anomalies also caused changes to documentation …