Authors
Mary Kyobula, Aremu Adedeji, Morgan R Alexander, Ehab Saleh, Ricky Wildman, Ian Ashcroft, Paul R Gellert, Clive J Roberts
Publication date
2017/9/10
Journal
Journal of Controlled release
Volume
261
Pages
207-215
Publisher
Elsevier
Description
A hot melt 3D inkjet printing method with the potential to manufacture formulations in complex and adaptable geometries for the controlled loading and release of medicines is presented. This first use of a precisely controlled solvent free inkjet printing to produce drug loaded solid dosage forms is demonstrated using a naturally derived FDA approved material (beeswax) as the drug carrier and fenofibrate as the drug. Tablets with bespoke geometries (honeycomb architecture) were fabricated. The honeycomb architecture was modified by control of the honeycomb cell size, and hence surface area to enable control of drug release profiles without the need to alter the formulation. Analysis of the formed tablets showed the drug to be evenly distributed within the beeswax at the bulk scale with evidence of some localization at the micron scale. An analytical model utilizing a Fickian description of diffusion was developed …
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