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In this study, 42 female Wistar albino rats, weighing between 200 and 250g, were used and they were divided into six equal groups. Group 1 was allocated as the control group. Rats included in groups 2 and 3 were administered a water-solubilized extract of bee pollen at a dose of 50mg/kg bw/day and 100mg/kg bw/day, respectively. Group 4 received 225mg/kg bw/day carbaryl. Groups 5 and 6 were given a water-solubilized extract of bee pollen at a dose of 50mg/kg bw/day and 100mg/kg bw/day, respectively, plus 225mg/kg bw/day carbaryl. The indicated administrations were continued for 21 days for groups 1–6 by gavage. MDA levels and the activities of CAT, SOD and GSH-Px were analysed in blood and tissues (liver, kidney, brain and heart). At the same time, levels/activities of total protein, albumin, glucose, triglyceride, T-cholesterol, T-bilirubin, BUN, creatinine, uric acid, GGT, LDH, AST, ALT and ALP …