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This study examined the relationships among four predictors (functional limitations, perceived visibility of condition, and two disability-associated affective responses— anxiety and depression), coping strategies, and two outcome measures of psychosocial adaptation to disability (disability-specific psychosocial adjustment and life satisfaction). Based on responses from 121 university students with disabilities, two models (additive and mediational) were tested to investigate the contribution of coping strategies to psychosocial adaptation to disability. The findings of this exploratory study suggest that coping strategies add significantly to the variance in both outcome measures after controlling for the contribution of disability-related factors. The role of coping strategies as mediators between the set of predictor and outcome variables was mostly unsupported in this sample, however. Reasons for the latter finding are …