Authors
Nora K Moog, Claudia Buss, Sonja Entringer, Babak Shahbaba, Daniel L Gillen, Calvin J Hobel, Pathik D Wadhwa
Publication date
2016/5/15
Journal
Biological psychiatry
Volume
79
Issue
10
Pages
831-839
Publisher
Elsevier
Description
Background
The effects of exposure to childhood trauma (CT) may be transmitted across generations; however, the time period(s) and mechanism(s) have yet to be clarified. We address the hypothesis that intergenerational transmission may begin during intrauterine life via the effect of maternal CT exposure on placental-fetal stress physiology, specifically placental corticotropin-releasing hormone (pCRH).
Methods
The study was conducted in a sociodemographically diverse cohort of 295 pregnant women. CT exposure was assessed using the Childhood Trauma Questionnaire. Placental CRH concentrations were quantified in maternal blood collected serially over the course of gestation. Linear mixed effects and Bayesian piece-wise linear models were employed to test hypothesized relationships.
Results
Maternal CT exposure (CT+) was significantly associated with pCRH production. Compared with nonexposed …
Scholar articles
NK Moog, C Buss, S Entringer, B Shahbaba, DL Gillen… - Biological psychiatry, 2016