Authors
Roland von Känel, Joel E Dimsdale, Sonia Ancoli‐Israel, Paul J Mills, Thomas L Patterson, Christine L McKibbin, Christopher Archuleta, Igor Grant
Publication date
2006/3
Journal
Journal of the American Geriatrics Society
Volume
54
Issue
3
Pages
431-437
Publisher
Blackwell Publishing Inc
Description
OBJECTIVES: To determine whether objective measures of sleep correlate with plasma levels of the proinflammatory cytokine interleukin (IL)‐6 and the procoagulant marker fibrin D‐dimer in caregivers of patients with dementia.
DESIGN: Cross‐sectional study.
SETTING: Subjects' homes.
PARTICIPANTS: Sixty‐four community‐dwelling spousal caregivers (69% women, mean age±standard deviation 72±9) and 36 sex‐matched noncaregiving controls.
MEASUREMENTS: All participants underwent in‐home full‐night polysomnography. Demographic and lifestyle factors, depression, diseases, and medication that could affect inflammation, coagulation, and sleep were controlled for in analyses regressing sleep variables and caregiver status and their interaction on plasma levels of IL‐6 and D‐dimer.
RESULTS: Caregivers had higher levels of D‐dimer (781±591 vs 463±214 ng/mL, P=.001) and IL‐6 (1.42±1.52 vs …
Total citations
Scholar articles
R von Känel, JE Dimsdale, S Ancoli‐Israel, PJ Mills… - Journal of the American Geriatrics Society, 2006