Authors
Roland Von Känel, Joel E Dimsdale, Paul J Mills, Sonia Ancoli-Israel, Thomas L Patterson, Brent T Mausbach, Igor Grant
Publication date
2006/9/1
Journal
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Volume
61
Issue
9
Pages
963-969
Publisher
Oxford University Press
Description
Background. Elevated plasma levels of interleukin (IL)-6, C-reactive protein (CRP), and D-dimer belong to the biological alterations of the “frailty syndrome,” defining increased vulnerability for diseases and mortality with aging. We hypothesized that, compatible with premature frailty, chronic stress and age are related in predicting inflammation and coagulation activity in Alzheimer caregivers.
Methods. Plasma IL-6, CRP, and D-dimer levels were measured in 170 individuals (mean age 73 ± 9 years; 116 caregivers, 54 noncaregiving controls). Demographic factors, diseases, drugs, and lifestyle variables potentially affecting inflammation and coagulation were obtained by history and adjusted for as covariates in statistical analyses.
Results. Caregivers had higher mean levels of IL-6 (1.38 ± 1.42 vs 1.00 ± 0.92 pg/mL, p =.032) and of D-dimer (723 ± 530 vs 471 ± …
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R Von Känel, JE Dimsdale, PJ Mills, S Ancoli-Israel… - The Journals of Gerontology Series A: Biological …, 2006