Authors
Julia R Ellis, Kathryn A Ellis, Cali F Bartholomeusz, Ben J Harrison, Keith A Wesnes, Fiona F Erskine, Luis Vitetta, Pradeep J Nathan
Publication date
2006/4/1
Journal
International Journal of Neuropsychopharmacology
Volume
9
Issue
2
Pages
175-189
Publisher
Cambridge University Press
Description
Functional abnormalities in muscarinic and nicotinic receptors are associated with a number of disorders including Alzheimer's disease and schizophrenia. While the contribution of muscarinic receptors in modulating cognition is well established in humans, the effects of nicotinic receptors and the interactions and possible synergistic effects between muscarinic and nicotinic receptors have not been well characterized in humans. The current study examined the effects of selective and simultaneous muscarinic and nicotinic receptor antagonism on a range of cognitive processes. The study was a double-blind, placebo-controlled, repeated measures design in which 12 healthy, young volunteers completed cognitive testing under four acute treatment conditions: placebo (P); mecamylamine (15 mg) (M); scopolamine (0.4 mg i.m.) (S); mecamylamine (15 mg)/scopolamine (0.4 mg i.m.) (MS). Muscarinic receptor …
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Scholar articles
JR Ellis, KA Ellis, CF Bartholomeusz, BJ Harrison… - International Journal of Neuropsychopharmacology, 2006