Authors
Alex Fornito, Ben J Harrison, Emmeline Goodby, Anna Dean, Cinly Ooi, Pradeep J Nathan, Belinda R Lennox, Peter B Jones, John Suckling, Edward T Bullmore
Publication date
2013/11/1
Journal
JAMA psychiatry
Volume
70
Issue
11
Pages
1143-1151
Publisher
American Medical Association
Description
Importance
Dysregulation of corticostriatal circuitry has long been thought to be critical in the etiology of psychotic disorders, although the differential roles played by dorsal and ventral systems in mediating risk for psychosis have been contentious.
Objective
To use resting-state functional magnetic resonance imaging to characterize disease-related, risk-related, and symptom-related changes of corticostriatal functional circuitry in patients with first-episode psychosis and their unaffected first-degree relatives.
Design, Setting, and Participants
This case-control cross-sectional study was conducted at a specialist early psychosis clinic, GlaxoSmithKline Clinical Unit, and magnetic resonance imaging facility. Nineteen patients with first-episode psychosis, 25 of their unaffected first-degree relatives, and 26 healthy control subjects were included in this study.
Main Outcomes and Measures
Voxelwise statistical parametric maps …
Scholar articles
A Fornito, BJ Harrison, E Goodby, A Dean, C Ooi… - JAMA psychiatry, 2013