Authors
Dominique Farge, Corneliu Henegar, Maryvonnick Carmagnat, Marjan Daneshpouy, Zora Marjanovic, Claire Rabian, Doina Ilie, Corinne Douay, Nicolas Mounier, Emmanuel Clave, Djaouida Bengoufa, Jean Cabane, Jean Pierre Marolleau, Eliane Gluckman, Dominique Charron, Antoine Toubert, Intensification et Autogreffe dans les Maladies Auto Immunes Résistantes (ISAMAIR) Study Group
Publication date
2005/5
Journal
Arthritis & Rheumatism
Volume
52
Issue
5
Pages
1555-1563
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Description
Objective
To analyze hematopoietic and immune reconstitution after autologous hematopoietic stem cell transplantation (HSCT) in 7 patients with systemic sclerosis (SSc).
Methods
Two groups of patients were retrospectively constituted according to whether they had a favorable clinical response (group A; n = 4) or no response or a relapse of disease (group B; n = 3) after HSCT. Immune reconstitution was analyzed every 3 months using lymphocyte immunophenotyping, α/β T cell receptor (TCR) diversity analysis, and ex vivo thymic function analysis by quantification of TCR rearrangement excision circles (TRECs).
Results
Patients had similar characteristics at study entry, except for a lower modified Rodnan skin thickness score (P = 0.03) and a lower Health Assessment Questionnaire score (P = 0.05) in group A than in group B. The number of reinjected cells and the time to hematopoietic reconstitution were …
Total citations
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Scholar articles
D Farge, C Henegar, M Carmagnat, M Daneshpouy… - Arthritis & Rheumatism, 2005