Authors
Laura Ernande, Etienne Audureau, Christine L Jellis, Cyrille Bergerot, Corneliu Henegar, Daigo Sawaki, Gabor Czibik, Chiara Volpi, Florence Canoui-Poitrine, Helene Thibault, Julien Ternacle, Philippe Moulin, Thomas H Marwick, Genevieve Derumeaux
Publication date
2017/10/3
Journal
Journal of the American College of Cardiology
Volume
70
Issue
14
Pages
1704-1716
Publisher
American College of Cardiology Foundation
Description
Background
Type 2 diabetes mellitus (T2DM) may alter cardiac structure and function, but obesity, hypertension (HTN), or aging can induce similar abnormalities.
Objectives
This study sought to link cardiac phenotypes in T2DM patients with clinical profiles and outcomes using cluster analysis.
Methods
Baseline echocardiography and a composite endpoint (cardiovascular mortality and hospitalization) were evaluated in 842 T2DM patients from 2 prospective cohorts. A cluster analysis was performed on echocardiographic variables, and the association between clusters and clinical profiles and outcomes was assessed.
Results
Three clusters were identified. Cluster 1 patients had the lowest left ventricular (LV) mass index and ratio between early mitral inflow velocity and mitral annular early diastolic velocity (E/e′) ratio, had the highest left ventricular ejection fraction (LVEF), and were predominantly male with the …
Scholar articles
L Ernande, E Audureau, CL Jellis, C Bergerot… - Journal of the American College of Cardiology, 2017