Authors
Saskia P Hagenaars, Sarah E Harris, Gail Davies, William David Hill, David CM Liewald, Stuart J Ritchie, Riccardo E Marioni, Chloe Fawns-Ritchie, Breda Cullen, Rainer Malik, Bradford B Worrall, Cathie LM Sudlow, Joanna M Wardlaw, John Gallacher, Jill Pell, Andrew M McIntosh, Daniel J Smith, Catharine R Gale, Ian J Deary
Publication date
2016/11
Journal
Molecular psychiatry
Volume
21
Issue
11
Pages
1624-1632
Publisher
Nature Publishing Group
Description
Causes of the well-documented association between low levels of cognitive functioning and many adverse neuropsychiatric outcomes, poorer physical health and earlier death remain unknown. We used linkage disequilibrium regression and polygenic profile scoring to test for shared genetic aetiology between cognitive functions and neuropsychiatric disorders and physical health. Using information provided by many published genome-wide association study consortia, we created polygenic profile scores for 24 vascular–metabolic, neuropsychiatric, physiological–anthropometric and cognitive traits in the participants of UK Biobank, a very large population-based sample (N= 112 151). Pleiotropy between cognitive and health traits was quantified by deriving genetic correlations using summary genome-wide association study statistics and to the method of linkage disequilibrium score regression. Substantial and …
Scholar articles
SP Hagenaars, SE Harris, G Davies, WD Hill… - Molecular psychiatry, 2016