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Recently, automated disease diagnosis based on medical images has become an integral component of digital pathology packages. Texture analysis is commonly used to address this issue, particularly in the context of estimating the osteoporosis progression in bone samples. Most research in this context uses handcrafted methods to directly extract bones image features despite the substantial correlation between sick and healthy bones, which explains the limited results. In this work, the handcrafted feature extraction method (e.g. HOG and/or LPQ) will be applied to a set of descriptors obtained from a deep analysis of bone texture images using Gabor's filter bank. In addition, the classifier automatically adjusts the Gabor filters settings, using the bat-inspired algorithm based optimization, to achieve deep analysis behavior and optimal performance. Using a typically osteoporosis database, our experimental results …