Authors
Andrew D Bretherick, Simon J McGrath, Andy Devereux-Cooke, Sian Leary, Emma Northwood, Anna Redshaw, Pippa Stacey, Claire Tripp, Jim Wilson, Sonya Chowdhury, Isabel Lewis, Øyvind Almelid, Sumy V Baby, Tom Baker, Hannes Becher, Thibaud Boutin, Malgorzata Clyde, Diana Garcia, John Ireland, Shona M Kerr, Ewan McDowall, David Perry, Gemma L Samms, Veronique Vitart, Jareth C Wolfe, Chris P Ponting
Publication date
2023
Journal
NIHR open research
Volume
3
Publisher
Department of Health and Social Care (UK)
Description
Background:
People with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) experience core symptoms of post-exertional malaise, unrefreshing sleep, and cognitive impairment. Despite numbering 0.2-0.4% of the population, no laboratory test is available for their diagnosis, no effective therapy exists for their treatment, and no scientific breakthrough regarding pathogenesis has been made. It remains unknown, despite decades of small-scale studies, whether individuals experience different types of ME/CFS separated by onset-type, sex or age.
Methods:
DecodeME is a large population-based study of ME/CFS that recruited 17,074 participants in the first 3 months following full launch. Detailed questionnaire responses from UK-based participants who all reported being diagnosed with ME/CFS by a health professional provided an unparalleled opportunity to investigate, using logistic regression, whether …
Total citations
Scholar articles
AD Bretherick, SJ McGrath, A Devereux-Cooke… - NIHR open research, 2023