Authors
Linda Repetto, Jiantao Chen, Zhijian Yang, Ranran Zhai, Paul RHJ Timmers, Ting Li, Emma L Twait, Sebastian May-Wilson, Marisa D Muckian, Bram P Prins, Grace Png, Charles Kooperberg, Åsa Johansson, Robert F Hillary, Eleanor Wheeler, Lu Pan, Yazhou He, Sofia Klasson, Shahzad Ahmad, James E Peters, Arthur Gilly, Maria Karaleftheri, Emmanouil Tsafantakis, Jeffrey Haessler, Ulf Gyllensten, Sarah E Harris, Nicholas J Wareham, Andreas Göteson, Cecilia Lagging, Mohammad Arfan Ikram, Cornelia M van Duijn, Christina Jern, Mikael Landén, Claudia Langenberg, Ian J Deary, Riccardo E Marioni, Stefan Enroth, Alexander P Reiner, George Dedoussis, Eleftheria Zeggini, Adam S Butterworth, Anders Mälarstig, James F Wilson, Pau Navarro, Xia Shen
Publication date
2023/3/31
Journal
Research square
Publisher
American Journal Experts
Description
Understanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioral traits and the disease etiology of neuropsychiatric disorders. Here, the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,500 individuals for 184 neuro-related proteins in human plasma. The analysis identified 117 cis-regulatory protein quantitative trait loci (cis-pQTL) and 166 trans-pQTL. The mapped pQTL capture on average 50% of each protein’s heritability. Mendelian randomization analyses revealed multiple proteins showing potential causal effects on neuro-related traits such as sleeping, smoking, feelings, alcohol intake, mental health, and psychiatric disorders. Integrating with established drug information, we validated 13 out of 13 matched combinations of protein targets and diseases or side effects with available drugs, while suggesting …
Scholar articles
L Repetto, J Chen, Z Yang, R Zhai, PRHJ Timmers, T Li… - Research square, 2023