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Devices and methods are provided for the clinical anal ysis of a sperm sample. The devices comprise a solid substrate, typically on the order of a few millimeters thick and approximately 0.2 to 2.0 centimeters square, microfabricated to define a sample inlet port and a me soscale flow channel extending from the inlet port. In one embodiment, a sperm sample is applied to the inlet port, and the competitive migration of the sperm sample through the mesoscale flow channel is detected to serve as an indicator of sperm motility. In another embodi ment, the substrate of the device is microfabricated with a sperm inlet port, an egg nesting chamber, and an elon gate mesoscale flow channel communicating between the egg nesting chamber and the inlet port. In this em bodiment, a sperm sample is applied to the inlet port, and the sperm in the sample are permitted to competi tively migrate from the inlet port through the …