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3,799,742 3/1974 Coleman............................... 422/61 Devices are provided for analyzing a? uid cell contain 3.906, 929 9/1975 Augspurger.'........ 435/2 ing sample. The devices comprise a solid substrate, 4,233,029 11/1930 Columbus------422/55 microfabricated to de? ne at least one sample inlet port 4,302,313 11/1981 Columbus...... 422/68 and a mésoscale? ow system_ The mesoscale? ow sys_ 4’350’768 9/1982 Tlho “ct a1 ‘'"""" 435/2 tem includes a sample? ow channel, extending from the 4,618,476 10/1986 Columbus 422/100.... 4 676 274 M19 “Brown 422/82 1nlet port, and a cell handlmg reg1on for treating cells

’’'''''''''" disposed in? uid communication with the flow channel. 4,790,640 12/1988 N.................. 350/534 _ _ _ _

4,386,761 12/1989 62552250,, et a1. __ 436/513 The dCVlCCS may further include a structure inducing 4,906,439 3/1990 Grenner.................... 422/56? ow of cells in the Sample through the …