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AASLDA b st ra ct s 1063 INCIDENCE AND FACTORS ASSOCIATED WITH HEPATITIS B SURFACE ANTIGEN LOSS IN A MULTIETHNIC COHORT OF CHRONIC HEPATITIS B PATIENTS Asif A. Hitawala, Elizabeth Wright, Janet Johnston, Chriss Homan, Brian J. McMahon, Marc G. Ghany Background and Aims: Among patients with chronic hepatitis B (CHB), the rate of sponta-neous hepatitis B surface antigen (HBsAg) loss is low,~ 1%. How race affects HBsAg loss is unclear as prior studies have been restricted to homogenous racial cohorts. To investigate the influence of race on rates of HBsAg loss we assessed the incidence and factors associated with HBsAg loss in a multiracial cohort of CHB patients. Methods: Data from 3 prospective, longitudinal cohorts of CHB patients were analyzed. The HEP-B-AK cohort included patients followed at the Alaska Native Tribal Health Consortium (ANTHC); The Hepatitis B …