Authors
Pauline Maciel August, Caroline Peres Klein, Mateus Grings, João Pedro Sagini, Patricia Idalina de Lemos Rodrigues, Daniela Pereira Stocher, Vinicius Stone, Yasmini Dandara Silva, Pablo Ribeiro Gonçalves Couto, Tiago Boeira Salomon, Mara da Silveira Benfato, Guilhian Leipnitz, Cristiane Matté
Publication date
2022/10/3
Journal
Nutritional Neuroscience
Volume
25
Issue
10
Pages
2066-2076
Publisher
Taylor & Francis
Description
Introduction
Polyphenols are compounds found in plants that have been extensively studied due to the health benefits of its consumption in adulthood. Meanwhile, recent evidence suggests that polyphenol consumption during pregnancy may not be safe for the fetus.
Objective
The goal of this study was to evaluate the effect of naringenin supplementation during pregnancy on brain redox homeostasis and mitochondrial activity of the newborn rat.
Methods
Adult female Wistar rats were divided into two groups: (1) vehicle (1 mL/Kg p.o.) or (2) naringenin (50 mg/Kg p.o.). Naringenin was administered once a day during pregnancy. The offspring were euthanized on postnatal day 7, as well the dams, and brain regions were dissected.
Results
The offspring cerebellum was the most affected region, presenting increased activity of the mitochondrial electron transport system, allied to increased reactive species levels, lipid …
Total citations
20242
Scholar articles
PM August, CP Klein, M Grings, JP Sagini… - Nutritional Neuroscience, 2022