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Big five personality traits, social support and coping styles were examined as predictors of three dimensions of burnout on the sample of 214 nurses using hierarchical regression analyses. Personality traits were included into the first step of the analyses, three sources of social support (co-workers, family and friends support) in the second, and in the third step three coping styles (problem-focused coping, emotion-focused coping and avoidance coping). The results show that out of five personality traits neuroticism positively predicted exhaustion, while agreeableness negatively predicted reduced professional efficacy. Regarding three sources of social support, only co-worker support negatively predicted exhaustion as well as reduced professional efficacy. Regarding coping styles examined, only avoidance coping positively predicted depersonalization. The results obtained were explained by several mechanisms through which personality variables may exert their effects on burnout.