Authors
Katherine H Ingram, Helliner Hill, Douglas R Moellering, Bradford G Hill, Cristina Lara-Castro, Bradley Newcomer, L Jerome Brandon, Christopher P Ingalls, Meera Penumetcha, Jeffrey C Rupp, W Timothy Garvey
Publication date
2012/7/1
Journal
The Journal of Clinical Endocrinology & Metabolism
Volume
97
Issue
7
Pages
E1182-E1186
Publisher
Oxford University Press
Description
Objective
The relationships among skeletal muscle lipid peroxidation, intramyocellular lipid content (IMCL), and insulin sensitivity were evaluated in nine insulin-sensitive (IS), 13 insulin-resistant (IR), and 10 adults with type 2 diabetes (T2DM).
Design
Insulin sensitivity was assessed by hyperinsulinemic-euglycemic clamp [glucose disposal rate (GDR)]. Lipid peroxidation was assessed by 4-hydroxynonenal (HNE)-protein adducts and general oxidative stress by protein carbonyl content. All patients were sedentary.
Results
Protein-HNE adducts were elevated 1.6-fold in T2DM compared with IS adults, whereas IR showed intermediate levels of HNE-modified proteins. Protein-HNE adducts correlated with GDR, waist circumference, and body mass index. IMCL was increased by 4.0- and 1.9-fold in T2DM and IR patients, respectively, compared with IS, and …
Scholar articles
KH Ingram, H Hill, DR Moellering, BG Hill… - The Journal of Clinical Endocrinology & Metabolism, 2012