Authors
Wendy Thomson, Anne Barton, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Rachelle Donn, Deborah Symmons, Samantha Hider, Ian N Bruce, Wellcome Trust Case Control Consortium Wilson Anthony G 2 Marinou Ioanna 2, Anthony G Wilson, Ioanna Marinou, Ann Morgan, Paul Emery, YEAR Consortium, Angela Carter, Sophia Steer, Lynne Hocking, David M Reid, Paul Wordsworth, Pille Harrison, David Strachan, Jane Worthington
Publication date
2007/12
Journal
Nature genetics
Volume
39
Issue
12
Pages
1431-1433
Publisher
Nature Publishing Group US
Description
The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 × 10−5 − 5 × 10−7 in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 × 10−8) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-α–induced protein 3 (TNFAIP3).
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Scholar articles
W Thomson, A Barton, X Ke, S Eyre, A Hinks, J Bowes… - Nature genetics, 2007