Authors
Eli A Stahl, Soumya Raychaudhuri, Elaine F Remmers, Gang Xie, Stephen Eyre, Brian P Thomson, Yonghong Li, Fina AS Kurreeman, Alexandra Zhernakova, Anne Hinks, Candace Guiducci, Robert Chen, Lars Alfredsson, Christopher I Amos, Kristin G Ardlie, BIRAC Consortium, Anne Barton, John Bowes, Elisabeth Brouwer, Noel P Burtt, Joseph J Catanese, Jonathan Coblyn, Marieke JH Coenen, Karen H Costenbader, Lindsey A Criswell, J Bart A Crusius, Jing Cui, Paul IW de Bakker, Philip L De Jager, Bo Ding, Paul Emery, Edward Flynn, Pille Harrison, Lynne J Hocking, Tom WJ Huizinga, Daniel L Kastner, Xiayi Ke, Annette T Lee, Xiangdong Liu, Paul Martin, Ann W Morgan, Leonid Padyukov, Marcel D Posthumus, Timothy RDJ Radstake, David M Reid, Mark Seielstad, Michael F Seldin, Nancy A Shadick, Sophia Steer, Paul P Tak, Wendy Thomson, Annette HM van der Helm-van Mil, Irene E van der Horst-Bruinsma, C Ellen van der Schoot, Piet LCM van Riel, Michael E Weinblatt, Anthony G Wilson, Gert Jan Wolbink, B Paul Wordsworth, Year Consortium, Cisca Wijmenga, Elizabeth W Karlson, Rene EM Toes, Niek de Vries, Ann B Begovich, Jane Worthington, Katherine A Siminovitch, Peter K Gregersen, Lars Klareskog, Robert M Plenge
Publication date
2010/6
Journal
Nature genetics
Volume
42
Issue
6
Pages
508-514
Publisher
Nature Publishing Group US
Description
To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid arthritis (cases) and 20,169 controls of European descent, followed by replication in an independent set of 6,768 rheumatoid arthritis cases and 8,806 controls. Of 34 SNPs selected for replication, 7 new rheumatoid arthritis risk alleles were identified at genome-wide significance (P < 5 × 10−8) in an analysis of all 41,282 samples. The associated SNPs are near genes of known immune function, including IL6ST, SPRED2, RBPJ, CCR6, IRF5 and PXK. We also refined associations at two established rheumatoid arthritis risk loci (IL2RA and CCL21) and confirmed the association at AFF3. These new associations bring the total number of confirmed rheumatoid arthritis risk loci to 31 among individuals of European ancestry. An additional 11 …
Total citations
Scholar articles
EA Stahl, S Raychaudhuri, EF Remmers, G Xie, S Eyre… - Nature genetics, 2010