Authors
Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, Tohoku Medical Megabank Project Study Group, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto
Publication date
2020/2/1
Source
International journal of epidemiology
Volume
49
Issue
1
Pages
18-19m
Publisher
Oxford University Press
Description
Although a large sample size is useful for the elucidation of what is called ‘missing heritability’, which is an unexplained part of a total phenotypic variance in a quantitative trait or familial disease aggregation, in prospective genome cohort studies, additional strategies may be required. 1 Historically, many patient-based cohort studies have been conducted with limited environmental information for the period preceding the onset of diseases. 2–6 Population-based prospective cohort designs have since been improved, and many risk factors for diseases have been identified. 7–10 Once the importance of in utero exposures was recognized, birth cohorts were also developed, 11–18 and were used to examine the lifelong effects of in utero exposures. 19 Because a study assessing disease risk throughout a person’s lifespan requires exposure and outcome measurements in multiple generations with long-term follow …
Scholar articles
S Kuriyama, H Metoki, M Kikuya, T Obara, M Ishikuro… - International journal of epidemiology, 2020