Authors
Amrou Sarraj, Ameer E Hassan, Michael G Abraham, Santiago Ortega-Gutierrez, Scott E Kasner, M Shazam Hussain, Michael Chen, Spiros Blackburn, Clark W Sitton, Leonid Churilov, Sophia Sundararajan, Yin C Hu, Nabeel A Herial, Pascal Jabbour, Daniel Gibson, Adam N Wallace, Juan F Arenillas, Jenny P Tsai, Ronald F Budzik, William J Hicks, Osman Kozak, Bernard Yan, Dennis J Cordato, Nathan W Manning, Mark W Parsons, Ricardo A Hanel, Amin N Aghaebrahim, Teddy Y Wu, Pere Cardona-Portela, Natalia Pérez de la Ossa, Joanna D Schaafsma, Jordi Blasco, Navdeep Sangha, Steven Warach, Chirag D Gandhi, Timothy J Kleinig, Daniel Sahlein, Lucas Elijovich, Wondwossen Tekle, Edgar A Samaniego, Laith Maali, M Ammar Abdulrazzak, Marios N Psychogios, Ashfaq Shuaib, Deep K Pujara, Faris Shaker, Hannah Johns, Gagan Sharma, Vignan Yogendrakumar, Felix C Ng, Mohammad H Rahbar, Chunyan Cai, Philip Lavori, Scott Hamilton, Thanh Nguyen, Johanna T Fifi, Stephen Davis, Lawrence Wechsler, Vitor M Pereira, Maarten G Lansberg, Michael D Hill, James C Grotta, Marc Ribo, Bruce C Campbell, Gregory W Albers
Publication date
2023/4/6
Journal
New England Journal of Medicine
Volume
388
Issue
14
Pages
1259-1271
Publisher
Massachusetts Medical Society
Description
Background
Trials of the efficacy and safety of endovascular thrombectomy in patients with large ischemic strokes have been carried out in limited populations.
Methods
We performed a prospective, randomized, open-label, adaptive, international trial involving patients with stroke due to occlusion of the internal carotid artery or the first segment of the middle cerebral artery to assess endovascular thrombectomy within 24 hours after onset. Patients had a large ischemic-core volume, defined as an Alberta Stroke Program Early Computed Tomography Score of 3 to 5 (range, 0 to 10, with lower scores indicating larger infarction) or a core volume of at least 50 ml on computed tomography perfusion or diffusion-weighted magnetic resonance imaging. Patients were assigned in a 1:1 ratio to endovascular thrombectomy plus medical care or to medical care alone. The primary outcome was the modified Rankin scale …
Total citations
Scholar articles
A Sarraj, AE Hassan, MG Abraham, S Ortega-Gutierrez… - New England Journal of Medicine, 2023