Authors
John R de Almeida, Wendy R Parulekar, Apostolos Christopoulos, Isabelle C Gauthier, Rosemary Martino, Andrea McNiven, Anthony C Nichols, Ambika Parmar, Eitan Prisman, Jolie Ringash, Martin Smoragiewicz, Rathan M Subramaniam, John Waldron, Steven B Chinn, James Edward Bates, Kate Whelan, Wei Tu, Ali Hosni
Publication date
2023/6/1
Source
Journal of Clinical Oncology
Volume
41
Issue
16_suppl
Pages
TPS6114-TPS6114
Publisher
American Society of Clinical Oncology
Description
TPS6114
Background: Lymphatic mapping identifies neck lymph nodes at risk for cancer spread in patients with lateralized oropharyngeal (OPC) squamous cell carcinoma. We hypothesize that a lymphatic mapping guided approach to radiotherapy (RT) treatment of the contralateral neck will enable safe de-escalation of therapy with acceptable disease control with potential benefits in RT related toxicity, QOL, swallowing function and economics. Methods: HN.11 is a Canadian Cancer Trials Group international multi-centre, non-inferiority randomized phase III trial comparing a lymphatic mapping-guided approach for management of the contralateral neck (experimental) vs. bilateral neck radiation therapy (RT) (control). The primary objective is to determine if a lymphatic mapping-guided approach for management of the contralateral neck has a non-inferior disease-free survival (DFS) compared to bilateral neck RT …
Total citations
20242
Scholar articles
JR de Almeida, WR Parulekar, A Christopoulos… - 2023