Authors
Wouter H van Geffen, Marcel Bruins, Huib AM Kerstjens
Publication date
2016/6/16
Journal
Journal of breath research
Volume
10
Issue
3
Pages
036001
Publisher
IOP Publishing
Description
Respiratory infections, viral or bacterial, are a common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). A rapid, point-of-care, and easy-to-use tool distinguishing viral and bacterial from other causes would be valuable in routine clinical care. An electronic nose (e-nose) could fit this profile but has never been tested in this setting before. In a single-center registered trial (NTR 4601) patients admitted with AECOPD were tested with the Aeonose® electronic nose, and a diagnosis of viral or bacterial infection was obtained by bacterial culture on sputa and viral PCR on nose swabs. A neural network with leave-10%-out cross-validation was used to assess the e-nose data. Forty three patients were included. In the bacterial infection model, 22 positive cases were tested versus the negatives; and similarly 18 positive cases were tested in the viral infection model. The Aeonose was able to …
Scholar articles
WH van Geffen, M Bruins, HAM Kerstjens - Journal of breath research, 2016
Diagnosing viral and bacterial respiratory infections in acute COPD exacerbations by electronic nose*
WH Van Geffen, H Kerstjens - Eur Respir J, 2016