Authors
Femke NG van’t Hof, Ynte M Ruigrok, Cue Hyunkyu Lee, Stephan Ripke, Graig Anderson, Mariza De Andrade, Annette F Baas, Jan D Blankensteijn, Erwin P Böttinger, Matthew J Bown, Joseph Broderick, Philippe Bijlenga, David S Carrell, Dana C Crawford, David R Crosslin, Christian Ebeling, Johan G Eriksson, Myriam Fornage, Tatiana Foroud, Mikael von Und Zu Fraunberg, Christoph M Friedrich, Emília I Gaál, Omri Gottesman, Dong‐Chuan Guo, Seamus C Harrison, Juha Hernesniemi, Albert Hofman, Ituro Inoue, Juha E Jääskeläinen, Gregory T Jones, Lambertus ALM Kiemeney, Riku Kivisaari, Nerissa Ko, Seppo Koskinen, Michiaki Kubo, Iftikhar J Kullo, Helena Kuivaniemi, Mitja I Kurki, Aki Laakso, Dongbing Lai, Suzanne M Leal, Hanna Lehto, Scott A LeMaire, Siew‐Kee Low, Jennifer Malinowski, Catherine A McCarty, Dianna M Milewicz, Thomas H Mosley, Yusuke Nakamura, Hirofumi Nakaoka, Mika Niemelä, Jennifer Pacheco, Peggy L Peissig, Joanna Pera, Laura Rasmussen‐Torvik, Marylyn D Ritchie, Fernando Rivadeneira, Andre M van Rij, Regie Lyn P Santos‐Cortez, Athanasios Saratzis, Agnieszka Slowik, Atsushi Takahashi, Gerard Tromp, André G Uitterlinden, Shefali S Verma, Sita H Vermeulen, Gao T Wang, Aneurysm Consortium; Vascular Research Consortium of New Zealand, Buhm Han, Gabriël JE Rinkel, Paul IW de Bakker, Matthew J Bown, Seamus C Harrison, Athanasios Saratzis, Ana Verissimo, Benjamin J Wright, Suzannah Bumpstead, Annette F Baas, Solveig Gretarsdottir, Stephen A Badger, Anne H Child, Rachel E Clough, Gillian Cockerill, Hany Hafez, D Julian A Scott, Simon Futers, Soroush Sohrabi, Alberto Smith, Matthew M Thompson, Frank M van Bockxmeer, Stefan E Matthiasson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Jan D Blankensteijn, Joep AW Teijink, Cisca Wijmenga, Jacqueline de Graaf, Lambertus A Kiemeney, Jutta Palmen, Andrew J Smith, Jes S Lindholt, Declan T Bradley, Matthew Waltham, Sarah Edkins, Rhian Gwilliam, Sarah E Hunt, Simon Potter, Jonathan Golledge, Per Eriksson, Paul E Norman, Janet T Powell, Kari Stefansson, John R Thompson, Steve E Humphries, Robert D Sayers, Panos Deloukas, Nilesh J Samani, Gregory T Jones, L Victoria Phillip, Andre M van Rij, Geraldine B Hill, Michael JA Williams, Ian A Thomson, Jo Krysa, Gerard T Wilkins, Tony R Merriman, Thodor M Vasudevan, David R Lewis, Ross D Blair, Andrew A Hill
Publication date
2016/7/14
Journal
Journal of the American Heart Association
Volume
5
Issue
7
Pages
e002603
Description
Background
Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co‐occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs.
Methods and Results
We performed a mega‐analysis of 1000 Genomes Project‐imputed genome‐wide association study (GWAS) data of 4 previously published aneurysm cohorts: 2 IA cohorts (in total 1516 cases, 4305 controls), 1 AAA cohort (818 cases, 3004 controls), and 1 TAA cohort (760 cases, 2212 controls), and observed associations of 4 known IA, AAA, and/or TAA risk loci (9p21, 18q11, 15q21, and 2q33) with consistent effect directions in all 4 cohorts. We calculated polygenic scores based on IA‐, AAA‐, and TAA‐associated SNPs and tested these scores for association to case‐control status in the other aneurysm …
Scholar articles
FNG van't Hof, YM Ruigrok, CH Lee, S Ripke… - Journal of the American Heart Association, 2016