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Mantle plume fixity has long been a cornerstone assumption to reconstruct past tectonic plate motions. However, precise geochronological and paleomagnetic data along Pacific continuous hotspot tracks have revealed substantial drift of the Hawaiian plume. The question remains for evidence of drift for other mantle plumes. Here, we use plume-derived basalts from the Mid-Atlantic ridge to confirm that the upper-mantle thermal anomaly associated with the Azores plume is asymmetric, spreading over ~2,000 km southwards and ~600 km northwards. Using for the first time a 3D-spherical mantle convection where plumes, ridges and plates interact in a fully dynamic way, we suggest that the extent, shape and asymmetry of this anomaly is a consequence of the Azores plume moving northwards by 1–2 cm/yr during the past 85 Ma, independently from other Atlantic plumes. Our findings suggest redefining the Azores …