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This study aimed to explore supportive needs of caregivers when caring for patients with chronic illness during hospitalization. A descriptive qualitative study was conducted at a tertiary hospital and purposive sampling was used to recruit 13 participants. Eligibility criteria included primary caregivers of patients with chronic illness. Data were collected via interviews. Results were analyzed using thematic analysis. Five themes were derived, portraying caregivers’ perceptions during the patients’ hospitalization. The caregivers generally appreciated patient care provided by healthcare professionals. However, they expressed the needs for complete and updated information regarding the patients’ conditions and training programs to enhance their knowledge and skills. Furthermore, they requested services to minimize their emotional and financial issues. Addressing caregivers’ supportive needs is important to augment the recovery of the patients and to reduce the rate of readmissions. Caregiver support programs can be offered to minimize emotional stress and to enhance their knowledge and skills.