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Objective: To measure the microsaccade characteristics of MS patients to quantify the presence of SWJ Background: MS is a neurodegenerative inflammatory disease of the CNS characterized by decline in neurological function that is partially ameliorated by existing therapies. Sensitive tools for tracking worsening are needed to help with the development of treatments to slow decline. Oculomotor deficits are common in MS and include disruption of normal fixation. The tracking scanning laser ophthalmoscope (TSLO), a high-resolution retinal eye-tracking device, can objectively quantify these deficits. Design/Methods: We recorded three, 10-second scans of fixational eye motion in 71 MS patients (average EDSS 3+/− 1.8, average disease duration 14.4+/− 19.4 years) to quantify the presence of SWJs. Eye traces were manually labeled to flag SWJs, defined by having two, roughly equal microsaccades of opposite …