View article

J. Neurochem. (2010) 113, 749–760.

Recent studies suggest that the chemotactic G protein‐coupled receptor formyl‐peptide‐receptor‐like‐1 (FPRL1) or the scavenger receptor MARCO (macrophage receptor with collagenous structure) plays an essential role in the inflammatory response of host defense mechanisms and neurodegenerative disorders such as Alzheimer’s disease. We therefore analyzed the involvement of FPRL1 and MARCO in amyloid β1–42 (Aβ1–42)‐induced signalling by extracellular‐signal regulated kinases 1/2 (ERK1/2) phosphorylation and cAMP level measurement in glial cells (astrocytes and microglia) and in transfected HEK293 cells. Receptors were inhibited by small interference RNA and the consequences in Aβ1–42‐ and MARCO agonist fucoidan‐induced signal transduction were determined. Receptor deactivation by antagonists or small interference RNA verified the …