Authors
Andrew Schrepf, Premal H Thaker, Michael J Goodheart, David Bender, George M Slavich, Laila Dahmoush, Frank Penedo, Koen DeGeest, Luis Mendez, David M Lubaroff, Steven W Cole, Anil K Sood, Susan K Lutgendorf
Publication date
2015/3/1
Journal
Psychoneuroendocrinology
Volume
53
Pages
256-267
Publisher
Pergamon
Description
Introduction
Hypothalamic-pituitary-adrenal (HPA) deregulation is commonly observed in cancer patients, but its clinical significance is not well understood. We prospectively examined the association between HPA activity, tumor-associated inflammation, and survival in ovarian cancer patients prior to treatment.
Materials and methods
Participants were 113 women with ovarian cancer who provided salivary cortisol for three days prior to treatment for calculation of cortisol slope, variability, and night cortisol. Cox proportional hazard regression analyses were used to examine associations between cortisol and survival in models adjusting for disease stage, tumor grade, cytoreduction and age. On a subsample of 41 patients with advanced disease ascites fluid was assayed for levels of interleukin-6 (IL-6) and correlated with cortisol variables.
Results
Each cortisol measure was associated with decreased survival time …
Scholar articles
A Schrepf, PH Thaker, MJ Goodheart, D Bender… - Psychoneuroendocrinology, 2015