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In this article, the territorial composition of the agriculture of the Aral Sea region of Uzbekistan, that is, the Republic of Karakalpakstan is analyzed. Scientific works of scientists from the CIS, Uzbekistan and Karakalpakstan on agricultural specialization were studied. The territorial structure of agriculture was first divided into three zones and analyzed. It is also studied within administrative-territorial units. The main goal of this research work is to analyze the territorial composition of agriculture in the Republic of Karakalpakstan.