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Aiming at exploring the influence of quality management systems (QMS) in staff’s work engagement and psychological empowerment in private institutions of social solidarity (IPSSs), this study performs a comparative analysis between institutions with and without an ISO 9001-based QMS. Data were collected through questionnaires applied to employees from two IPSSs with a certified QMS and two IPSSs without a QMS. Findings show that although employees’ perception about psychological empowerment and engagement are generally higher in IPSS with an ISO 9001-based QMS, these differences are not statistically significant. Nevertheless, in what empowerment concerns, the perception of employees with leading role in IPSS with an ISO 9001-based QMS is significantly greater than the perception of those in IPSS without a QMS. To our knowledge, no previous study has investigated the influence of ISO …