Authors
Paul Knekt, John Ritz, Mark A Pereira, Eilis J O'Reilly, Katarina Augustsson, Gary E Fraser, Uri Goldbourt, Berit L Heitmann, Göran Hallmans, Simin Liu, Pirjo Pietinen, Donna Spiegelman, June Stevens, Jarmo Virtamo, Walter C Willett, Eric B Rimm, Alberto Ascherio
Publication date
2004/12/1
Journal
The American journal of clinical nutrition
Volume
80
Issue
6
Pages
1508-1520
Publisher
Elsevier
Description
Background
Epidemiologic studies have suggested a lower risk of coronary heart disease (CHD) at higher intakes of fruit, vegetables, and whole grain. Whether this association is due to antioxidant vitamins or some other factors remains unclear.
Objective
We studied the relation between the intake of antioxidant vitamins and CHD risk.
Design
A cohort study pooling 9 prospective studies that included information on intakes of vitamin E, carotenoids, and vitamin C and that met specific criteria was carried out. During a 10-y follow-up, 4647 major incident CHD events occurred in 293 172 subjects who were free of CHD at baseline.
Results
Dietary intake of antioxidant vitamins was only weakly related to a reduced CHD risk after adjustment for potential nondietary and dietary confounding factors. Compared with subjects in the lowest dietary intake quintiles for vitamins E and C, those in the highest intake quintiles had …
Total citations
Scholar articles
P Knekt, J Ritz, MA Pereira, EJ O'Reilly, K Augustsson… - The American journal of clinical nutrition, 2004
P Knekt, J Ritz, MA Pereira, EJ O'Reilly, K Augustsson… - American Journal of Clinical Nutrition, 2004