Authors
Marianne U Jakobsen, Eilis J O’Reilly, Berit L Heitmann, Mark A Pereira, Katarina Bälter, Gary E Fraser, Uri Goldbourt, Göran Hallmans, Paul Knekt, Simin Liu, Pirjo Pietinen, Donna Spiegelman, June Stevens, Jarmo Virtamo, Walter C Willett, Alberto Ascherio
Publication date
2009/5/1
Journal
The American journal of clinical nutrition
Volume
89
Issue
5
Pages
1425-1432
Publisher
Elsevier
Description
Background
Saturated fatty acid (SFA) intake increases plasma LDL-cholesterol concentrations; therefore, intake should be reduced to prevent coronary heart disease (CHD). Lower habitual intakes of SFAs, however, require substitution of other macronutrients to maintain energy balance.
Objective
We investigated associations between energy intake from monounsaturated fatty acids (MUFAs), polyunsaturated fatty acids (PUFAs), and carbohydrates and risk of CHD while assessing the potential effect-modifying role of sex and age. Using substitution models, our aim was to clarify whether energy from unsaturated fatty acids or carbohydrates should replace energy from SFAs to prevent CHD.
Design
This was a follow-up study in which data from 11 American and European cohort studies were pooled. The outcome measure was incident CHD.
Results
During 4–10 y of follow-up, 5249 coronary events and 2155 coronary …
Total citations
Scholar articles
MU Jakobsen, EJ O'Reilly, BL Heitmann, MA Pereira… - The American journal of clinical nutrition, 2009