Authors
Rebecca J Leeman‐Neill, Alina V Brenner, Mark P Little, Tetiana I Bogdanova, Maureen Hatch, Liudmyla Y Zurnadzy, Kiyohiko Mabuchi, Mykola D Tronko, Yuri E Nikiforov
Publication date
2013/5/15
Journal
Cancer
Volume
119
Issue
10
Pages
1792-1799
Publisher
Wiley Subscription Services, Inc., A Wiley Company
Description
BACKGROUND
Childhood exposure to iodine‐131 from the 1986 nuclear accident in Chernobyl, Ukraine, led to a sharp increase in papillary thyroid carcinoma (PTC) incidence in regions surrounding the reactor. Data concerning the association between genetic mutations in PTCs and individual radiation doses are limited.
METHODS
Mutational analysis was performed on 62 PTCs diagnosed in a Ukrainian cohort of patients who were < 18 years old in 1986 and received 0.008 to 8.6 Gy of 131I to the thyroid. Associations between mutation types and 131I dose and other characteristics were explored.
RESULTS
RET/PTC (ret proto‐oncogene/papillary thyroid carcinoma) rearrangements were most common (35%), followed by BRAF (15%) and RAS (8%) point mutations. Two tumors carrying PAX8/PPARγ (paired box 8/peroxisome proliferator‐activated receptor gamma) rearrangement were identified. A …
Scholar articles
RJ Leeman‐Neill, AV Brenner, MP Little, TI Bogdanova… - Cancer, 2013