Authors
Rebecca J Leeman‐Neill, Lindsey M Kelly, Pengyuan Liu, Alina V Brenner, Mark P Little, Tetiana I Bogdanova, Viktoria N Evdokimova, Maureen Hatch, Liudmyla Y Zurnadzy, Marina N Nikiforova, Ning J Yue, Miao Zhang, Kiyohiko Mabuchi, Mykola D Tronko, Yuri E Nikiforov
Publication date
2014/3/15
Journal
Cancer
Volume
120
Issue
6
Pages
799-807
Description
BACKGROUND
In their previous analysis of papillary thyroid carcinomas (PTCs) from an Ukrainian‐American cohort that was exposed to iodine‐131 (131I) from the Chernobyl accident, the authors identified RET/PTC rearrangements and other driver mutations in 60% of tumors.
METHODS
In this study, the remaining mutation‐negative tumors from that cohort were analyzed using RNA sequencing (RNA‐Seq) and reverse transcriptase‐polymerase chain reaction to identify novel chromosomal rearrangements and to characterize their relation with radiation dose.
RESULTS
The ETS variant gene 6 (ETV6)‐neurotrophin receptor 3 (NTRK3) rearrangement (ETV6‐NTRK3) was identified by RNA‐Seq in a tumor from a patient who received a high 131I dose. Overall, the rearrangement was detected in 9 of 62 (14.5%) post‐Chernobyl PTCs and in 3 of 151 (2%) sporadic PTCs (P = .019). The most common fusion …
Scholar articles
RJ Leeman‐Neill, LM Kelly, P Liu, AV Brenner… - Cancer, 2014