Authors
Enqi He, Miguel A Gonzalez Lozano, Sven Stringer, Kyoko Watanabe, Kensuke Sakamoto, Frank den Oudsten, Frank Koopmans, Stephanie N Giamberardino, Anke Hammerschlag, L Niels Cornelisse, Ka Wan Li, Jan van Weering, Danielle Posthuma, August B Smit, Patrick F Sullivan, Matthijs Verhage
Publication date
2018/6/1
Journal
Human molecular genetics
Volume
27
Issue
11
Pages
1879-1891
Publisher
Oxford University Press
Description
The MIR137 locus is a replicated genetic risk factor for schizophrenia. The risk-associated allele is reported to increase miR-137 expression and miR-137 overexpression alters synaptic transmission in mouse hippocampus. We investigated the cellular mechanisms underlying these observed effects in mouse hippocampal neurons in culture. First, we correlated the risk allele to expression of the genes in the MIR137 locus in human postmortem brain. Some evidence for increased MIR137HG expression was observed, especially in hippocampus of the disease-associated genotype. Second, in mouse hippocampal neurons, we confirmed previously observed changes in synaptic transmission upon miR-137 overexpression. Evoked synaptic transmission and spontaneous release were 50% reduced. We identified defects in release probability as the underlying cause. In contrast to previous observations, no …
Scholar articles
E He, MAG Lozano, S Stringer, K Watanabe… - Human molecular genetics, 2018